Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidylserine-diolein | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isozyme pKCalpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
commercial preparation | purified PKC from brain | Rattus norvegicus | - |
hematopoietic cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + hematopoietic-specific G-protein Galpha15 | recombinant substrate expressed in COS-7 cells, phosphorylation at Ser334, mutant G-protein Galpha15 S334A is inactive as substrate for PKC | Rattus norvegicus | ADP + phosphorylated hematopoietic-specific G-protein Galpha15 | - |
? | |
ATP + hematopoietic-specific G-protein Galpha15 peptide | the PKC phosphorylation site peptide sequence RKGSR includes Ser334 | Rattus norvegicus | ADP + phosphorylated hematopoietic-specific G-protein Galpha15 peptide | - |
? | |
ATP + hematopoietic-specific G-protein Galpha16 | substrate from HL-60 cells, phosphorylation at Ser336, mutant G-protein Galpha16 S336A is inactive as substrate for PKC | Rattus norvegicus | ADP + phosphorylated hematopoietic-specific G-protein Galpha16 | - |
? | |
ATP + hematopoietic-specific G-protein Galpha16 peptide | the PKC phosphorylation site peptide sequence KKGARSRR includes Ser336 | Rattus norvegicus | ADP + phosphorylated hematopoietic-specific G-protein Galpha16 peptide | - |
? | |
additional information | phosphorylation by PKC is involved in regulation of hematopoietic-specific G-protein Galpha15 and Galpha16, deletion of the PKC phosphorylation site leads to inhibition of receptor-coupled phospholipase C activation | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |