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Literature summary for 2.7.11.13 extracted from

  • Kochs, G.; Hummel, R.; Meyer, D.; Hug, H.; Marme, D.; Sarre, T.F.
    Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes (1993), Eur. J. Biochem., 216, 597-606.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
arachidonic acid alone or a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity Homo sapiens
arachidonic acid slightly enhances PKC zeta activity Homo sapiens
diacylglycerol plus phosphatidylserine, activates Homo sapiens
gamma-linolenic acid a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity Homo sapiens
additional information cannot be activated by phorbol ester treatment of NIH 3T3 cells or insect cells, overexpressing the respective PKC isoenzyme Homo sapiens
phosphatidylserine plus diacylglycerol, activates Homo sapiens
phosphatidylserine a combination of gamma-linolenic acid and phosphatidylserine slightly enhances PKC zeta activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in recombinant baculovirus-infected insect cells Homo sapiens
expression in recombinant baculovirus-infected insect cells, overexpression in NIH 3T3 cells or insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information insensitive to PKC inhibitors known to interfere either with the regulatory or the catalytic domain Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activity is independent of Ca2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens constitutive enzyme ?
-
 ?
additional information Homo sapiens PKC zeta exhibits a constitutive kinase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05129
-
-
Homo sapiens Q05513
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens
partial purification of the PKC-zeta isoenzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + PKC-alpha-derived peptide in the presence of the classical PKC activators phosphatidylserine/diacylglycerol, PKC alpha phosphorylates a PKC-alpha pseudosubstrate-derived peptide, an epidermal-growth-factor-receptor-derived peptide, histone III-S and myelin basic protein to an equal extent, whilst PKC zeta phosphorylates only the PKC-alpha-derived peptide Homo sapiens ADP + phosphorylated PKC-alpha-derived peptide
-
 ?
additional information constitutive enzyme Homo sapiens ?
-
 ?
additional information PKC zeta exhibits a constitutive kinase Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKC-zeta
-
 Homo sapiens
protein kinase C, gamma type
-
 Homo sapiens
protein kinase C, zeta type
-
 Homo sapiens