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Literature summary for 2.7.11.11 extracted from

  • Coover, R.A.; Luzi, N.M.; Korwar, S.; Casile, M.E.; Lyons, C.E.; Peterson, D.L.; Ellis, K.C.
    Design, synthesis, and in vitro evaluation of a fluorescently labeled irreversible inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKACalpha) (2016), Org. Biomol. Chem., 14, 4576-4581.
    View publication on PubMed
Search for more literature for 2.7.11.11

Protein Variants

Protein Variants Comment Organism
C199A inactive Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
myr-PKI(14-22) reversible inhibitor Mus musculus
rhodamine B-PKI(14-22)-GFMK potent, competitive, irreversible inhibitor, 97% inhibition at 0.001 mM Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + phosphorylated protein
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P05132
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + phosphorylated protein
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase
-
 Mus musculus
PKACalpha catalytic subunit Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000118
-
 pH and temperature not specified in the publication Mus musculus rhodamine B-PKI(14-22)-GFMK
0.0000479
-
 pH and temperature not specified in the publication Mus musculus myr-PKI(14-22)