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Literature summary for 2.7.11.11 extracted from

  • Nedvetsky, P.I.; Zhao, X.; Mathivet, T.; Aspalter, I.M.; Stanchi, F.; Metzger, R.J.; Mostov, K.E.; Gerhardt, H.
    cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner (2016), Development, 143, 3582-3590.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Mus musculus
-
 ADP + phosphorylated protein
-
 ?
ATP + a protein Danio rerio
-
 ADP + phosphorylated protein
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
embryo
-
 Danio rerio
-
endothelium
-
 Mus musculus
-
endothelium
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Mus musculus ADP + phosphorylated protein
-
 ?
ATP + a protein
-
 Danio rerio ADP + phosphorylated protein
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase A
-
 Mus musculus
cAMP-dependent protein kinase A
-
 Danio rerio
PKA
-
 Mus musculus
PKA
-
 Danio rerio

General Information

General Information Comment Organism
malfunction enzyme inhibition leads to hypersprouting as a result of an increased number of tip cells Mus musculus
malfunction enzyme inhibition leads to hypersprouting as a result of an increased number of tip cells Danio rerio
physiological function endothelial cAMP-dependent protein kinase A activity is essential for vascular development, specifically regulating the transition from sprouting to stabilization of nascent vessels. The4 enzyme regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner Mus musculus
physiological function endothelial cAMP-dependent protein kinase A activity is essential for vascular development, specifically regulating the transition from sprouting to stabilization of nascent vessels. The4 enzyme regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner Danio rerio