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Literature summary for 2.7.11.11 extracted from

  • Paine, T.A.; Neve, R.L.; Carlezon, W.A.
    Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase (PKA) within the medial prefrontal cortex of rats (2009), Neuropsychopharmacology, 34, 2143-2155.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Sp-adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydrate activates PKA Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(Rp)-adenosine-3',5'-cyclic monophosphorothioate inhibits PKA Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex cell line medial prefrontal brain cortex Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cAMP response element binding protein the transcription factor cAMP response element binding protein is directly activated by PKA Rattus norvegicus ADP + phosphorylated cAMP response element binding protein
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Synonyms

Synonyms Comment Organism
cAMP dependent protein kinase
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Rattus norvegicus
PKA
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Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus
cAMP
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibition of PKA reduces accuracy in the 5-choice serial reaction time task and causes substantial increases in locomotor activity without affecting motivation or the capacity to emit operant responses at high rates, PKA inhibition within the medial prefrontal cortex of rats produces inattention and hyperactivity Rattus norvegicus