Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Sp-adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydrate | activates PKA | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Rp)-adenosine-3',5'-cyclic monophosphorothioate | inhibits PKA | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex cell line | medial prefrontal brain cortex | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + cAMP response element binding protein | the transcription factor cAMP response element binding protein is directly activated by PKA | Rattus norvegicus | ADP + phosphorylated cAMP response element binding protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP dependent protein kinase | - |
Rattus norvegicus |
PKA | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus | |
cAMP | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of PKA reduces accuracy in the 5-choice serial reaction time task and causes substantial increases in locomotor activity without affecting motivation or the capacity to emit operant responses at high rates, PKA inhibition within the medial prefrontal cortex of rats produces inattention and hyperactivity | Rattus norvegicus |