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Literature summary for 2.7.11.11 extracted from

  • Desiniotis, A.; Schaefer, G.; Klocker, H.; Eder, I.E.
    Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A (2010), Int. J. Cancer, 126, 775-789.
    View publication on PubMed
Search for more literature for 2.7.11.11

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
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 Homo sapiens
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LNCaP cell
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 Homo sapiens
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prostate cancer cell line
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
cyclic AMP-dependent protein kinase A
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 Homo sapiens
PKA
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 Homo sapiens
PKA RIalpha regulatory subunit I alpha of PKA Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
cAMP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction combined inhibition of the androgen receptor and the regulatory subunit I alpha of PKA with small interference RNAs significantly increases the growth-inhibitory and proapoptotic effects of androgen receptor knockdown. Downregulating PKA RIalpha is sufficient to inhibit PKA signaling and also impairs androgen receptor expression and activation. Depletion of PKA RIalpha also potentiates the antiproliferative effect of the antiandrogen bicalutamide in androgen-sensitive LNCaP cells Homo sapiens