Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dibutyryl-cAMP | - |
Rattus norvegicus | |
dibutyryl-cAMP | - |
Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
C199A | the mutant of the catalytic alpha-subunit in the holoenzyme leads to insensitivity towards H2O2 | Rattus norvegicus |
C199A | the mutant of the catalytic alpha-subunit in the holoenzyme leads to insensitivity towards H2O2 | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H-89 | - |
Bos taurus | |
H-89 | - |
Rattus norvegicus | |
H2O2 | H2O2 inhibits activation of PKA, but inhibition can be reverted with dithiothreitol or with thioredoxin reductase plus thioredoxin, H2O2 is ineffective if the PKA holoenzyme is preincubated with cAMP, if added to the catalytic alpha-subunit, which is active independently of cAMP activation, or if the catalytic alpha-subunit is substituted by ist C199A mutant in the reconstituted holoenzyme | Bos taurus | |
H2O2 | H2O2 inhibits activation of PKA, but inhibition can be reverted with dithiothreitol or with thioredoxin reductase plus thioredoxin, H2O2 is ineffective if the PKA holoenzyme is preincubated with cAMP, if added to the catalytic alpha-subunit, which is active independently of cAMP activation, or if the catalytic alpha-subunit is substituted by ist C199A mutant in the reconstituted holoenzyme | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipocyte | - |
Rattus norvegicus | - |
heart | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Kemptide | - |
Rattus norvegicus | ADP + Kemptide phosphate | - |
? | |
ATP + Kemptide | - |
Bos taurus | ADP + Kemptide phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Rattus norvegicus |
PKA | - |
Bos taurus |
protein kinase A | - |
Rattus norvegicus |
protein kinase A | - |
Bos taurus |
type IIbeta cyclic AMP-dependent protein kinase | - |
Rattus norvegicus |
type IIbeta cyclic AMP-dependent protein kinase | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus | |
ATP | - |
Bos taurus | |
cAMP | dependent | Rattus norvegicus | |
cAMP | dependent | Bos taurus |