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Literature summary for 2.7.11.11 extracted from
- Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A (2004), Mol. Cell. Biol., 24, 765-773.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | dependent on | Homo sapiens |  |
| additional information | forskolin induces PKA activity | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H-89 | strong inhibition | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone deacetylase 8 | Homo sapiens | FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme | ADP + phosphorylated histone deacetylase 8 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + histone deacetylase 8 | FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme | Homo sapiens | ADP + phosphorylated histone deacetylase 8 | - |
? | |
| ATP + histone deacetylase 8 | class 1 histone deacetylase HDAC8, recombinantly expressed FLAG-tagged GST-fusion substrate protein, Ser39 is the major phosphorylation site, low activity with HDAC8 mutant S39A | Homo sapiens | ADP + phosphorylated histone deacetylase 8 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclic AMP-dependent protein kinase A | - |
Homo sapiens |
| PKA | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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