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Literature summary for 2.7.11.11 extracted from
- Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities (2005), J. Biol. Chem., 280, 28241-28250.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | dependent on | Homo sapiens |  |
| cAMP | dependent on | Bos taurus | |
| dibutyryl-cAMP | activates in vitro | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + G protein-coupled receptor GRK1 | Bos taurus | - |
ADP + phosphorylated G protein-coupled receptor GRK1 | - |
? | |
| ATP + G protein-coupled receptor GRK1 | Homo sapiens | recombinant FLAG-tagged GRK1 expressed in HEK-293 cells, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation | ADP + phosphorylated G protein-coupled receptor GRK1 | - |
? | |
| ATP + G protein-coupled receptor GRK7 | Bos taurus | - |
ADP + phosphorylated G protein-coupled receptor GRK7 | - |
? | |
| ATP + G protein-coupled receptor GRK7 | Homo sapiens | recombinant FLAG-tagged GRK1 expressed in HEK-293 cells, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation | ADP + phosphorylated G protein-coupled receptor GRK7 | - |
? | |
| additional information | Homo sapiens | regulation of GRK1 and GRK7 by cAMP level during light and dark phases | ? | - |
? | |
| additional information | Bos taurus | regulation of GRK1 and GRK7 by cAMP level during light and dark phases | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
| retina | - |
Bos taurus | - |
| retinal rod | - |
Homo sapiens | - |
| retinal rod | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + G protein-coupled receptor GRK1 | - |
Bos taurus | ADP + phosphorylated G protein-coupled receptor GRK1 | - |
? | |
| ATP + G protein-coupled receptor GRK1 | recombinant FLAG-tagged GRK1 expressed in HEK-293 cells, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation | Homo sapiens | ADP + phosphorylated G protein-coupled receptor GRK1 | - |
? | |
| ATP + G protein-coupled receptor GRK1 | phosphorylation at Ser21, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation, no activity with GRK1 mutant S21A | Homo sapiens | ADP + phosphorylated G protein-coupled receptor GRK1 | - |
? | |
| ATP + G protein-coupled receptor GRK1 | recombinant FLAG-tagged GRK1, phosphorylation at Ser21 | Bos taurus | ADP + phosphorylated G protein-coupled receptor GRK1 | - |
? | |
| ATP + G protein-coupled receptor GRK7 | - |
Bos taurus | ADP + phosphorylated G protein-coupled receptor GRK7 | - |
? | |
| ATP + G protein-coupled receptor GRK7 | recombinant FLAG-tagged GRK1 expressed in HEK-293 cells, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation | Homo sapiens | ADP + phosphorylated G protein-coupled receptor GRK7 | - |
? | |
| ATP + G protein-coupled receptor GRK7 | phosphorylation at Ser23 and Ser36, enzymatic inactivation of the receptor activity inhibiting rhodopsin phosphorylation, no activity with GRK1 mutants S23A/S36A and S23E/S36E | Homo sapiens | ADP + phosphorylated G protein-coupled receptor GRK7 | - |
? | |
| ATP + G protein-coupled receptor GRK7 | recombinant FLAG-tagged GRK7, phosphorylation at Ser23 and Ser36 | Bos taurus | ADP + phosphorylated G protein-coupled receptor GRK7 | - |
? | |
| additional information | regulation of GRK1 and GRK7 by cAMP level during light and dark phases | Homo sapiens | ? | - |
? | |
| additional information | regulation of GRK1 and GRK7 by cAMP level during light and dark phases | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Homo sapiens |
| PKA | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
| 30 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Homo sapiens |
| 7.6 | - |
assay at | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Bos taurus | |
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