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Literature summary for 2.7.11.11 extracted from

  • Constantinescu, A.; Wu, M.; Asher, O.; Diamond, I.
    cAMP-dependent protein kinase type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK (2004), J. Biol. Chem., 279, 43321-43329.
    View publication on PubMed
Search for more literature for 2.7.11.11

Activating Compound

Activating Compound Comment Organism Structure
cAMP dependent on Mus musculus
additional information phosphorylation of CBP by PKA type I is induced by forskolin and ethanol, inhibition of MAPK activates the PKA type I Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm activated type I PKA is not translocated to the nucleus Mus musculus 5737
-
nucleus activated type II PKA is translocated to the nucleus Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CRE-binding protein Mus musculus i.e. CREB, a transcription factor, activition by type I PKA ADP + CRE-binding phosphoprotein
-
 ?
ATP + CREB-binding protein Mus musculus i.e. CBP, activition by type II PKA ADP + CREB-binding phosphoprotein
-
 ?
additional information Mus musculus PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 2 types of PKA
-

Source Tissue

Source Tissue Comment Organism Textmining
NG-108-15 cell neuroblastoma x glioma hybrid cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CRE-binding protein i.e. CREB, a transcription factor, activition by type I PKA Mus musculus ADP + CRE-binding phosphoprotein
-
 ?
ATP + CREB-binding protein i.e. CBP, activition by type II PKA Mus musculus ADP + CREB-binding phosphoprotein
-
 ?
additional information PKA type I regulates ethanol-induced cAMP response element-mediated gene expression via activation of CREB-binding protein and inhibition of MAPK, regulation overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase type I
-
 Mus musculus
type I PKA
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus