Literature summary for 2.7.11.11 extracted from

Gardner, L.A.; Delos Santos, N.M.; Matta, S.G.; Whitt, M.A.; Bahouth, S.W.
Role of the cyclic AMP-dependent protein kinase in homologous resensitization of the beta1-adrenergic receptor (2004), J. Biol. Chem., 279, 21135-21143.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cAMP	dependent on	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction and expression of enzyme with inactive cAMP binding sites at the regulatory subunits resulting in impaired beta1-adrenergic receptor recycling in recombinant HEK-293 cells, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
H-89	specific inhibitor	Homo sapiens
myristoylated PKI	specific inhibitor	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + beta1-adrenergic receptor	Homo sapiens	recombinant beta1-adrenergic receptor expressed in HEK-293 cell membranes, phosphorylation at Ser312 is essential for activation of endocytic recycling of the agonist-internalized beta1-adrenergic receptor, beta1-AR mutant S312A is not recycled, overview	ADP + phosphorylated beta1-adrenergic receptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + beta1-adrenergic receptor	recombinant beta1-adrenergic receptor expressed in HEK-293 cell membranes, phosphorylation at Ser312 is essential for activation of endocytic recycling of the agonist-internalized beta1-adrenergic receptor, beta1-AR mutant S312A is not recycled, overview	Homo sapiens	ADP + phosphorylated beta1-adrenergic receptor	-	?
ATP + beta1-adrenergic receptor	phosphorylation at Ser312 in the third intracellular loop of the receptor protein by the PKA catalytic subunit	Homo sapiens	ADP + phosphorylated beta1-adrenergic receptor	-	?

Synonyms

Synonyms	Comment	Organism
cyclic AMP-dependent protein kinase	-	Homo sapiens
PKA	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)