Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | dependent on | Homo sapiens | |
additional information | beta-arrestin is not required for phosphorylation activity and receptor substrate endocytosis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction and expression of a mouse mutant beta-adrenergic receptor lacking the PKA phosphorylation sites in HEK-293 cells, and coexpression of murine GFP-tagged beta-arrestin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
H-89 | - |
Homo sapiens | |
additional information | caveolae inhibitors inhibit the internalization of the beta-adrenergic receptor by PKA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Homo sapiens | PKA phosphorylation mediates beta-1 adrenergic receptor endocytosis via the caveolae pathway | ADP + phosphorylated beta-adrenergic receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | PKA phosphorylation mediates beta-1 adrenergic receptor endocytosis via the caveolae pathway | Homo sapiens | ADP + phosphorylated beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | mouse wild-type receptor, cytosolic phosphorylation domain near the transmembrane domains of the substrate, overview | Homo sapiens | ADP + phosphorylated beta-adrenergic receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Homo sapiens |
protein kinase A | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |