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Literature summary for 2.7.11.11 extracted from

  • Biondi, R.M.; Nebreda, A.R.
    Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions (2003), Biochem. J., 372, 1-13.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

General Stability

General Stability Organism
N-terminal and C-terminal extensions stabilize the catalytic core Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PKI pseudo-substrate inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information recognition motif and phosphorylation sequences, substrate binding structure, peptide binding in an extended conformation, N-terminal and C-terminal extensions bind pseudosubstrates Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More the enzyme consists of an N-terminal small lobe and a C-terminal large lobe giving the catalytic core a bean-like structure and stabilizing the enzyme Homo sapiens

Synonyms

Synonyms Comment Organism
cAMP-dependent protein kinase
-
 Homo sapiens
PKA
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP binds between two lobes, directing the gamma-phosphate outwards while the adenine ring lies deep in the cleft between the lobes Homo sapiens