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Literature summary for 2.7.11.1 extracted from
- Casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis (2014), Mol. Biol. Cell, 25, 1629-1640 .
No PubMed abstract available
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme silencing by CK1delta siRNA, phenotype, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| PF670462 | a CK1delta/epsilon kinase inhibitor | Homo sapiens |  |
| PF670462 | a CK1delta/epsilon kinase inhibitor | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| centrosome | - |
Homo sapiens | 5813 | - |
| centrosome | - |
Mus musculus | 5813 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| Golgi apparatus | - |
Mus musculus | 5794 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens | |
| Mg2+ | required | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + AKAP450 | Homo sapiens | - |
ADP + phospho-AKAP450 | - |
? | |
| ATP + AKAP450 | Mus musculus | - |
ADP + phospho-AKAP450 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P48730 | - |
- |
| Mus musculus | Q9DC28 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | embryonic | Mus musculus | - |
| hTERT-RPE1 cell | - |
Mus musculus | - |
| kidney | inner medullary collecting duct cells-3 | Mus musculus | - |
| MEF cell | - |
Mus musculus | - |
| retinal pigment epithelial cell | telomerase reverse transcriptase immortalized retinal pigmented epithelial cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + AKAP450 | - |
Homo sapiens | ADP + phospho-AKAP450 | - |
? | |
| ATP + AKAP450 | - |
Mus musculus | ADP + phospho-AKAP450 | - |
? | |
| ATP + AKAP450 | wild-type substrate and GFP-tagged AKAP450 fragment containing the CK1delta-binding site | Homo sapiens | ADP + phospho-AKAP450 | - |
? | |
| ATP + AKAP450 | wild-type substrate and GFP-tagged AKAP450 fragment containing the CK1delta-binding site | Mus musculus | ADP + phospho-AKAP450 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casein kinase 1delta | - |
Homo sapiens |
| casein kinase 1delta | - |
Mus musculus |
| CK1delta | - |
Homo sapiens |
| CK1delta | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | casein kinase 1delta (CK1dellta) is an evolutionarily conserved serine/threonine kinase | Homo sapiens |
| evolution | casein kinase 1delta (CK1dellta) is an evolutionarily conserved serine/threonine kinase | Mus musculus |
| malfunction | inhibition of casein kinase 1 delta blocks primary ciliogenesis in human telomerase reverse transcriptase immortalized retinal pigmented epithelial cells. Overexpression of an AKAP450 fragment containing the CK1delta-binding site inhibits Golgi-derived microtubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and ciliogenesis. CK1delta inhibition also alters pericentrosomal or ciliary distribution of several proteins involved in ciliary transport, including centrosomal protein of 290 kDa, pericentriolar material protein 1, and polycystin-2, as well as the Golgi distribution of its binding partner, A-kinase anchor protein 450 (AKAP450). AKAP450 distribution is dispersed by CK1delta inhibition. Knockdown of CK1delta in hTERT-RPE cells stably expressing GFP-tagged IFT20 disrupts the intracellular distribution of IFT20, consistent with perturbation of the GM130 staining pattern | Homo sapiens |
| malfunction | inhibition of casein kinase 1 delta blocks primary ciliogenesis in mouse inner medullary collecting duct cells-3. Mouse embryonic fibroblasts and retinal cells from Csnk1delta-null mice also exhibit ciliogenesis defects. Overexpression of an AKAP450 fragment containing the CK1delta-binding site inhibits Golgi-derived microtubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and ciliogenesis. CK1delta inhibition also alters pericentrosomal or ciliary distribution of several proteins involved in ciliary transport, including centrosomal protein of 290 kDa, pericentriolar material protein 1, and polycystin-2, as well as the Golgi distribution of its binding partner, A-kinase anchor protein 450 (AKAP450). AKAP450 distribution is dispersed by CK1delta inhibition. CK1delta inhibition disrupts cis-Golgi organization, IFT20 distribution, and Golgi-derived microtubule nucleation, CK1delta siRNA significantly increases the Golgi diameter and centrosomeGolgi distance | Mus musculus |
| physiological function | casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis. CK1delta functions to coordinate the positioning and activity of multiple ciliary effectors, such as Rab11a and Rab8a, CEP290, PCM1, and IFT20, to mediate transport of polycystin-2 and other membrane cargo from the Golgi to the basal body and nascent cilium. CK1delta is required for microtubule nucleation at the Golgi and maintenance of Golgi integrity. CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi, where it is important for maintaining Golgi organization and polarized trafficking of multiple factors that mediate ciliary transport | Homo sapiens |
| physiological function | casein kinase 1delta functions at the centrosome and Golgi to promote ciliogenesis. CK1delta functions to coordinate the positioning and activity of multiple ciliary effectors, such as Rab11a and Rab8a, CEP290, PCM1, and IFT20, to mediate transport of polycystin-2 and other membrane cargo from the Golgi to the basal body and nascent cilium. CK1delta is required for microtubule nucleation at the Golgi and maintenance of Golgi integrity. CK1delta mediates primary ciliogenesis by multiple mechanisms, one involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi, where it is important for maintaining Golgi organization and polarized trafficking of multiple factors that mediate ciliary transport. Expression of a truncated derivative containing the CLS displaces full-length CK1delta from the centrosome and decreases ciliary length in control MEFs, suggesting that centrosomal CK1delta has a role in ciliogenesis, structure-function analysis of CK1delta in MEF primary ciliogenesis, overview | Mus musculus |
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