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Literature summary for 2.7.11.1 extracted from

  • Sahu, A.; Koshinaka, K.; Sahu, M.
    Phosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus (2013), J. Neuroendocrinol., 25, 168-179.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.1

Inhibitors

Inhibitors Comment Organism Structure
Wortmannin a specific PI3K inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Rattus norvegicus Sprague-Dawley
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
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 Rattus norvegicus
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brain
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 Rattus norvegicus
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hepatocyte primary Rattus norvegicus
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hypothalamus
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 Rattus norvegicus
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Synonyms

Synonyms Comment Organism
phosphatidylinositol 3-kinase
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 Rattus norvegicus
PI3K
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus leptin induces the enzyme in the hypothalamus up

General Information

General Information Comment Organism
malfunction administration of wortmannin completely reversed the stimulatory effect of leptin on PDE3B activity in the hypothalamus Rattus norvegicus
metabolism leptin action through its receptor involves various pathways including the signal transducer and activator of transcription (STAT3), phosphatidylinositol 3-kinase(PI3K), and phosphodiesterase 3B (PDE3B)-cAMP signaling in the CNS and peripheral tissues. In the hypothalamus, leptin stimulates STAT3 activation, and induces PI3K and PDE3B activities, among others Rattus norvegicus
physiological function phosphatidylinositol 3-kinase is an upstream regulator of PDE3B in non-neuronal tissues, but it also is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt/protein kinase B in the rat hypothalamus. In adipocytes, insulin stimulates MAPK, p70S6 kinase and Akt through wortmannin sensitive mechanisms, i.e., PI3K mechanism, but the PDE3B activation by insulin is due to PKB phosphorylation, suggesting the role of PI3K-Akt-PDE3B pathway in insulin signaling Rattus norvegicus