Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Mus musculus | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P35991 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Mus musculus | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Bruton's tyrosine kinase | - |
Mus musculus |
Btk | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme-deficiency leads to a reduction in mature peripheral B cells. Enzyme-deficient mice fail to respond to immunization with type 2 thymus-independent antigens, and accordingly, peripheral B cells from these animals are unresponsive to B cell receptor crosslinking | Mus musculus |
physiological function | the enzyme is essential for B cell activation and differentiation | Mus musculus |