Application | Comment | Organism |
---|---|---|
medicine | in HT29 colon carcinoma cells, silencing of tyrosine kinase c-Yes, but not of kinase c-Src, selectively leads to an increase of cell clustering associated with a localisation of beta-catenin at cell membranes and a reduction of expression of beta-catenin target genes. c-Yes silencing induces an increase in apoptosis, inhibition of growth in soft-agar and in mouse xenografts, inhibition of cell migration and loss of the capacity to generate liver metastases in mice. Reintroduction of c-Yes, but not c -Src, restores transforming properties of c-Yes depleted cells. c-Yes kinase activity is required for its role in beta-catenin localisation and growth in soft agar, whereas kinase activity is dispensable for its role in cell migration. c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that are not shared with c-Src | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07947 | YES1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-29 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Yes | - |
Homo sapiens |
YES1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in HT29 colon carcinoma cells, silencing of tyrosine kinase c-Yes, but not of kinase c-Src, selectively leads to an increase of cell clustering associated with a localisation of beta-catenin at cell membranes and a reduction of expression of beta-catenin target genes. c-Yes silencing induces an increase in apoptosis, inhibition of growth in soft-agar and in mouse xenografts, inhibition of cell migration and loss of the capacity to generate liver metastases in mice. Reintroduction of c-Yes, but not c -Src, restores transforming properties of c-Yes depleted cells. c-Yes kinase activity is required for its role in beta-catenin localisation and growth in soft agar, whereas kinase activity is dispensable for its role in cell migration. c-Yes regulates specific oncogenic signalling pathways important for colon cancer progression that are not shared with c-Src | Homo sapiens |