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Literature summary for 2.7.10.2 extracted from
- Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes (2010), J. Biol. Chem., 285, 31174-31184.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | isoform Pyk2 is not a Ca2+-dependent kinase in T cells but instead, increased intracellular Ca2+ induces Pyk2 phosphorylation through production of reactive oxygen species. Ca2+-stimulated Pyk2 phosphorylation is dependent on Src-family kinase activity, even at the Pyk2 autophosphorylation site. Pyk2 phosphorylation in cytotoxic T-lymphocytes is not absolutely Ca2+-dependent but relies on the strength of T-cell receptor stimulation | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q14289 | PYK2 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| proline-rich tyrosine kinase 2 | - |
Homo sapiens |
| PTK2B | - |
Homo sapiens |
| Pyk2 | - |
Homo sapiens |
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