Literature summary for 2.7.10.2 extracted from

Kim, E.J.; Monje, F.J.; Li, L.; Hoeger, H.; Pollak, D.D.; Lubec, G.
Alzheimer's disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory (2013), Cell. Mol. Life Sci., 70, 743-759.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
neuron	primary culture of hippocampal neuron	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Lck	-	Mus musculus
lymphocyte-specific protein tyrosine kinase	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	specific pharmacological inhibition and genetic silencing indicate the involvement of isoform Lck in the regulation of neuritic outgrowth. Specific Lck inhibition also selectively impairs the long-term hippocampal synaptic plasticity without affecting spontaneous excitatory synaptic transmission or short-term synaptic potentiation and significantly alters hippocampus-dependent spatial learning and memory in vivo	Mus musculus

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Release 2023.1 (January 2023)