Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | exposure of BE(2)-C cells to the heavy metals Cd2+ and Hg2+ and to rotenone inhibits interleukin-6, interferon-gamma and ciliary neurotrophic factor-mediated Jak/STAT signaling, reduces Jak1 and Jak2 autophosphorylation and induces Jak tyrosine nitration by mitochondrial disruption. Identical exposure of HepG2 hepatoma cells produces no inhibition of these cytokine responses. | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
SK-N-BE(2)C cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + signal transducer and activator of transcription | - |
Homo sapiens | ADP + phospho-L-tyrosinyl-signal transducer and activator of transcription | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Jak tyrosine kinase | - |
Homo sapiens |
Jak1 | - |
Homo sapiens |
JAK2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |