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Literature summary for 2.7.10.2 extracted from

  • Pesu, M.; Laurence, A.; Kishore, N.; Zwillich, S.H.; Chan, G.; O‘Shea, J.J.
    Therapeutic targeting of Janus kinases (2008), Immunol. Rev., 223, 132-142.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Protein Variants

Protein Variants Comment Organism
additional information Tyk2 mutations are associated with autosomal recessive hyperimmunoglobulin E or JobÂ’s syndrome Homo sapiens
V617F JAK2 gain-of-function mutation underlying myeloproliferative diseases Mus musculus
V617F JAK2 gain-of-function mutation underlying myeloproliferative diseases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CP-690,550 has nanomolar potency in in vitro JAK2 and JAK3 kinase assays Homo sapiens
CP-690,550 has nanomolar potency in in vitro JAK2 and JAK3 kinase assays Mus musculus
INCB18424 Incyte Homo sapiens
INCB18424 Incyte Mus musculus
XL019 Exelixis Homo sapiens
XL019 Exelixis Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Mus musculus
Mg2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Mus musculus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation Mus musculus
phosphoprotein Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Mus musculus ADP + a [protein]-L-tyrosine phosphate
-
 ?
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
JAK2
-
 Mus musculus
JAK2
-
 Homo sapiens
Jak3
-
 Mus musculus
Jak3
-
 Homo sapiens
Janus kinase
-
 Mus musculus
Janus kinase
-
 Homo sapiens
Tyk2
-
 Mus musculus
Tyk2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction mutations of JAK3 may be a cause of severe combined immunodeficiency Homo sapiens
malfunction mutations of JAK3 may be a cause of severe combined immunodeficiency, JAK3 knockout mice have a profound reduction in thymic progenitor cells and reduced ability to reconstitute T cell development, in the periphery, CD8+ T and NK cells are severely reduced. JAK3- (and gamma chain) deficient mice also have severely defective B cell development, deficiency of JAK1 and JAK2 is lethal Mus musculus
physiological function JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23 Mus musculus
physiological function JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23 Homo sapiens