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Literature summary for 2.7.10.2 extracted from

  • Jedidi, A.; Marty, C.; Oligo, C.; Jeanson-Leh, L.; Ribeil, J.A.; Casadevall, N.; Galy, A.; Vainchenker, W.; Villeval, J.L.
    Selective reduction of JAK2V617F-dependent cell growth by siRNA/shRNA and its reversal by cytokines (2009), Blood, 114, 1842-1851.
    View publication on PubMed
Search for more literature for 2.7.10.2

Protein Variants

Protein Variants Comment Organism
V617F the mutation is responsible for the majority of breakpoint cluster region/Abelson -negative myeloproliferative disorders Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AZ960 potent and selective ATP competitive inhibitor of JAK2 enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60674
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
HEL cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
PBMC cell CD34+ Homo sapiens
-
SET-2 cell
-
 Homo sapiens
-
UKE-1 cell
-
 Homo sapiens
-
UT-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
JAK2
-
 Homo sapiens
Janus kinase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens