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Literature summary for 2.7.10.2 extracted from

  • Lin, J.; Arlinghaus, R.
    Activated c-Abl tyrosine kinase in malignant solid tumors (2008), Oncogene, 27, 4385-4391.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
epithelial growth factor receptor
-
 Homo sapiens
insulin-like growth factor 1 receptor
-
 Homo sapiens
additional information phosphorylation of Y245 and Y412 leads to the activation of Abl kinase Homo sapiens
platelet-derived growth factor receptor
-
 Homo sapiens
Src activated Src kinase in aggressive breast cancer cell lines can activate c-Abl kinase Homo sapiens

Application

Application Comment Organism
medicine the activated c-Abl tyrosine kinase plays an important role in malignant solid tumors of lung and breast, mutant forms are involved in hematopoietic malignancies such as chronic myeloid leukemia, CML Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Bcr protein negative regulator Homo sapiens
F-actin negative regulator Homo sapiens
Fus1 protein negative regulator Homo sapiens
imatinib mesylate Gleevec Homo sapiens
additional information c-Abl is downregulated in part by intramolecular interactions that provide autoinhibitory kinase effects Homo sapiens
PAG protein negative regulator Homo sapiens
phosphoinositide negative regulator Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the oncogenic effects of Abl are believed to reside in cytoplasmic forms of c-Abl Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
MDA-MB-435 cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
c-ABL
-
 Homo sapiens
c-Abl tyrosine kinase
-
 Homo sapiens