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Literature summary for 2.7.10.2 extracted from

  • Palmer, C.D.; Mutch, B.E.; Workman, S.; McDaid, J.P.; Horwood, N.J.; Foxwell, B.M.
    Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkappaB activity (2008), Blood, 111, 1781-1788.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide
-
 Homo sapiens

Application

Application Comment Organism
medicine the results have important implications for the design of therapeutics targeted against specific cytokines and their regulators in inflammatory disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant, replication-deficient adenoviral constructs encoding wild-type human Bmx and HA-tagged Bmx are prepared Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
RNAi knockdown of Btk results in decreased tumor necrosis factor-alpha Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P51813
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Bmx tyrosine kinase
-
 Homo sapiens
Btk tyrosine kinase
-
 Homo sapiens