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Literature summary for 2.7.10.2 extracted from

  • Sirvent, A.; Benistant, C.; Roche, S.
    Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells (2008), Biol. Cell., 100, 617-631.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
angiotensin subtype 1 receptor AT-1 receptor Homo sapiens
Epidermal growth factor EGF Homo sapiens
additional information c-Abl is regulated also by phosphorylation Homo sapiens
platelet-derived growth factor PDGF Homo sapiens
transforming growth factor beta receptor TGF-beta receptor Homo sapiens

Application

Application Comment Organism
medicine the importance of de-regulated c-Abl cytoplasmic signalling in solid tumours is discussed Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
actin cytoskeleton
-
 Homo sapiens 15629
-
cytoplasm
-
 Homo sapiens 5737
-
cytosol
-
 Homo sapiens 5829
-
membrane
-
 Homo sapiens 16020
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information isoform 1b has a myristoylation site Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
c-Abl tyrosine kinase isoforms 1a and 1b Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens