Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine | PP2, AG-1897 | Homo sapiens | |
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine | PP2, AG-1897 | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
determined by SDS-PAGE and Western Blot analysis | Mus musculus |
60000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Mus musculus | - |
ADP + [protein]-L-tyrosine phosphate | - |
? | |
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P12931 | - |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared | Mus musculus |
protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HL-1 cell | HL-1 cardiomyocyte | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine | substrate HCN4, tyrosine 531 is phosphorylated | Mus musculus | ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate | - |
? | |
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine | substrate HCN4, tyrosine 531 is phosphorylated | Homo sapiens | ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate | - |
? | |
ATP + [protein]-L-tyrosine | - |
Mus musculus | ADP + [protein]-L-tyrosine phosphate | - |
? | |
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Src tyrosine kinase | - |
Mus musculus |
Src tyrosine kinase | - |
Homo sapiens |