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Literature summary for 2.7.10.2 extracted from

  • Li, C.H.; Zhang, Q.; Teng, B.; Mustafa, S.J.; Huang, J.Y.; Yu, H.G.
    Src tyrosine kinase alters gating of hyperpolarization-activated HCN4 pacemaker channel through Tyr531 (2008), Am. J. Physiol. Cell Physiol., 294, C355-C362.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, AG-1897 Homo sapiens
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, AG-1897 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
determined by SDS-PAGE and Western Blot analysis Mus musculus
60000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Mus musculus
-
ADP + [protein]-L-tyrosine phosphate
-
?
ATP + [protein]-L-tyrosine Homo sapiens
-
ADP + [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P12931
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared Mus musculus
protein extracts from cells, transfected with plasmids containing the HCN4 gene, are prepared Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
HL-1 cell HL-1 cardiomyocyte Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine substrate HCN4, tyrosine 531 is phosphorylated Mus musculus ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
-
?
ATP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine substrate HCN4, tyrosine 531 is phosphorylated Homo sapiens ADP + [hyperpolarization-activated, cyclic nucleotide-gated 4 channel]-L-tyrosine phosphate
-
?
ATP + [protein]-L-tyrosine
-
Mus musculus ADP + [protein]-L-tyrosine phosphate
-
?
ATP + [protein]-L-tyrosine
-
Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
Src tyrosine kinase
-
Mus musculus
Src tyrosine kinase
-
Homo sapiens