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Literature summary for 2.7.10.2 extracted from

  • Yu, J.H.; Wang, H.J.; Li, X.R.; Tashiro, S.; Onodera, S.; Ikejima, T.
    Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells (2008), Acta Pharmacol. Sin., 29, 1069-1076.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
pseudolaric acid B pseudolaric acid B, PAB, activates PTK to induce apoptosis Homo sapiens

Application

Application Comment Organism
medicine due to their involvement in various forms of cancer, PTK have become prominent targets for therapeutic intervention Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AG1024
-
Homo sapiens
genistein
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
ADP + [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
Protein tyrosine kinase
-
Homo sapiens
PTK
-
Homo sapiens