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Literature summary for 2.7.10.2 extracted from

  • Ulanova, M.; Asfaha, S.; Stenton, G.; Lint, A.; Gilbertson, D.; Schreiber, A.; Befus, D.
    Involvement of Syk protein tyrosine kinase in LPS-induced responses in macrophages (2007), J. Endotoxin Res., 13, 117-125.
    View publication on PubMed
Search for more literature for 2.7.10.2

Protein Variants

Protein Variants Comment Organism
additional information siRNA Syk knockout, overview, preparation of a stem loop rat aerosolized Syk antisense-liposome complexes leading to downregulation of airway inflammatory responses, overview Rattus norvegicus
additional information Syk silencing in TNP1-cells by siRNA interference leads to inhibition of lipopolysaccharide-induced responses in the cells, and to downregulation of IL-6 and IL-8 release, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview ?
-
 ?
additional information Rattus norvegicus Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
leukocyte
-
 Rattus norvegicus
-
macrophage
-
 Homo sapiens
-
macrophage peritoneal and alveolar Rattus norvegicus
-
mast cell
-
 Homo sapiens
-
mast cell
-
 Rattus norvegicus
-
THP-1 cell a myelocytic cell line Homo sapiens
-
trachea
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview Homo sapiens ?
-
 ?
additional information Syk protein tyrosine kinase is involved in lipopolysaccharide-induced responses and intracellular signaling leading to release of pro-inflammatory mediators in macrophages, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Syk
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus