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Literature summary for 2.7.10.2 extracted from

  • Ortolano, S.; Hwang, I.Y.; Han, S.B.; Kehrl, J.H.
    Roles for phosphoinositide 3-kinases, Brutons tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing (2006), Eur. J. Immunol., 36, 1285-1295.
    View publication on PubMed
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
LFM-A13 significantly impairs CXCL12-induced human B lymphoma cell line, and blocks Akt activation, homing of transferred B cells to peripheral lymph nodes is impaired, LFM-A13 significantly reduces the CXCL12-induced increases in Ca2+, overview Homo sapiens
LFM-A13 significantly impairs CXCL12-induced mouse B cell chemotaxis, and blocks Akt activation, homing of transferred B cells to peripheral lymph nodes is impaired, LFM-A13 significantly reduces the CXCL12-induced increases in Ca2+, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview ?
-
 ?
additional information Homo sapiens Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell lymphoma cell
-
 Mus musculus
-
B-cell lymphoma cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview Mus musculus ?
-
 ?
additional information Brutons tyrosine kinase is involved in B lymphocyte chemotaxis and homing, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Brutons tyrosine kinase
-
 Mus musculus
Brutons tyrosine kinase
-
 Homo sapiens
Btk
-
 Mus musculus
Btk
-
 Homo sapiens