Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Syk is activated by phosphorylation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of siRNA of Syk or the domainant-negative Syk mutat DN-Syk in HL-60 cells leads to inhibition of phagocytosis, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | protein-tyrosine kinase Syk plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system, and is required for pathogen engulfment in complement-mediated phagocytosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Syk is activated by phosphorylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | macrophage-like differentiated | Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
monocyte | primary | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | protein-tyrosine kinase Syk plays a central role in Fcgamma receptor-mediated phagocytosis in the adaptive immune system, and is required for pathogen engulfment in complement-mediated phagocytosis | Homo sapiens | ? | - |
? | |
additional information | Syk affects actin dynamics around the C3bi-mediated phagosomes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Protein-tyrosine kinase Syk | - |
Homo sapiens |
Syk | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |