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Literature summary for 2.7.10.2 extracted from

  • Arnaud, L.; Ballif, B.A.; Cooper, J.A.
    Regulation of protein tyrosine kinase signaling by substrate degradation during brain development (2003), Mol. Cell. Biol., 23, 9293-9302.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
Reelin extracellular, stimulates disabled-1 adaptor protein Dab1 tyrosine phosphorylation by Src family PTKs, downregulates Dab1 expression in vivo Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp2, inhibits Src family PTKs Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [disabled-1 adaptor protein]-L-tyrosine Mus musculus activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
 ?
ATP + [disabled-1 adaptor protein]-L-tyrosine Mus musculus C57BL6J/129Sv activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 hybrid C57BL6J/129Sv
-
Mus musculus C57BL6J/129Sv
-
 hybrid C57BL6J/129Sv
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
embryo
-
 Mus musculus
-
neuron primary embryonic, cortical neuron cultures Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [disabled-1 adaptor protein]-L-tyrosine
-
 Mus musculus ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
 ?
ATP + [disabled-1 adaptor protein]-L-tyrosine activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview Mus musculus ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
 ?
ATP + [disabled-1 adaptor protein]-L-tyrosine
-
 Mus musculus C57BL6J/129Sv ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
 ?
ATP + [disabled-1 adaptor protein]-L-tyrosine activation of disabled-1 adaptor protein Dab1, which is responsible for regulation of neuronal migrations during mammalian brain development, Reelin induces tyrosine-phosphorylated-Dab1 degradation and downregulates Dab1 expression in primary cortical neurons, mutant non-phosphorylated Dab1 are not degraded, pathway regulation, overview Mus musculus C57BL6J/129Sv ADP + [disabled-1 adaptor protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
More PTKs of the Src kinase family Mus musculus
Protein tyrosine kinase
-
 Mus musculus
PTK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus