Cloned (Comment) | Organism |
---|---|
expression of VSV-tagged wild-type Syk and catalytically inactive mutant Syk K- in MCF-10A cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | epidermal growth factor receptor EGFR induces Syk inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | Syk main localization | Homo sapiens | 5737 | - |
membrane | Syk is colocalized with EGFR | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | spleen tyrosine kinase Syk modulates epidermal growth factor receptor EGFR signalling in mammary epithelial cells acting as a negative controle element, regulation of EGFR by activation of the autophosphorylation activity of EGFR, but not of HER2 and HER3, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | epithelium, Syk occurs in MDA-MB-468 cells, but not in BT-549 cells | Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
MCF-10A cell | breast epithelial cell line | Homo sapiens | - |
MDA-MB-468 cell | breast cancer cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | spleen tyrosine kinase Syk modulates epidermal growth factor receptor EGFR signalling in mammary epithelial cells acting as a negative controle element, regulation of EGFR by activation of the autophosphorylation activity of EGFR, but not of HER2 and HER3, overview | Homo sapiens | ? | - |
? | |
additional information | Syk performs autophosphorylation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Spleen tyrosine kinase | - |
Homo sapiens |
Syk | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |