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Literature summary for 2.7.10.2 extracted from

  • Watanabe, N.; Broome, M.; Hunter, T.
    Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle (1995), EMBO J., 14, 1878-1891.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cyclin-associated cyclin-dependent kinase Homo sapiens Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15 ADP + phosphorylated cyclin-associated cyclin-dependent kinase
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 ?
additional information Homo sapiens activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2 ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P30291
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Source Tissue

Source Tissue Comment Organism Textmining
additional information WEE1Hu activity increased during S and G2 phases in parallel with the level of protein. Its activity decreased at M phase when WEE1Hu becomes transiently hyperphosphorylated Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + cyclin-associated cyclin-dependent kinase phosphorylated on Y15 Homo sapiens ADP + phosphorylated cyclin-associated cyclin-dependent kinase
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 ?
ATP + cyclin-associated cyclin-dependent kinase Wee1 negatively regulates cyclin-dependent kinases by phosphorylation on Y15 Homo sapiens ADP + phosphorylated cyclin-associated cyclin-dependent kinase
-
 ?
additional information activity of WEE1Hu is regulated by phosphorylation and proteolytic degradation, WEE1Hu plays a role in inhibiting mitosis before M phase by phosphorylating cyclin B1-Cdc2 Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
WEE1hu
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 Homo sapiens