Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
eukaryota |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
eukaryota | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation regulates the enzyme activity, the enzyme is phosphorylated at the activation loop | eukaryota |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | regulation of enzyme activity involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated | eukaryota |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nonreceptor PTK | - |
eukaryota |
v-Fps | - |
eukaryota |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | the binding site is a deep pocket lined by hydrophobic residues, enzyme affinity of v-Fps for ATP is not influenced by phosphorylation of the activation loop | eukaryota |