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Literature summary for 2.7.10.2 extracted from

  • Isakov, N.; Wange, R.L.; Burgess, W.H.; Watts, J.D.; Aebersold, R.; Samelson, L.E.
    ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity (1995), J. Exp. Med., 181, 375-380.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens tandem ZAP-70 SH2 domains bind phosphorylated, but not nonphosphorylated, T cell antigen receptor zeta cyt. The NH2-terminal ZAP-70 SH2 domain also binds to T cell antigen receptor zeta cyt but with 100-fold lower affinity. No binding is observed with the COOH-terminal ZAP-70 SH2 domain. Similar studies demonstrate that the ZAP-70 tandem SH2 domain can bind a T cell antigen receptor zeta 3 TAM peptide in which both tyrosine residues are phosphorylated: Little or no binding is observed with peptides phosphorylated at only one tyrosine residue, or a nonphosphorylated peptide. Binding of the tandem SH2 domains to the other two TCR zeta TAM peptides and to a CD3 epsilon TAM peptide is also observed. All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70. The affinity of these peptides for the tandem SH2 construct demonstrates a hierarchy of TAM zeta 1, TAM zeta 2, TAM epsilon, TAM zeta 3 ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P43403
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information tandem ZAP-70 SH2 domains bind phosphorylated, but not nonphosphorylated, T cell antigen receptor zeta cyt. The NH2-terminal ZAP-70 SH2 domain also binds to T cell antigen receptor zeta cyt but with 100-fold lower affinity. No binding is observed with the COOH-terminal ZAP-70 SH2 domain. Similar studies demonstrate that the ZAP-70 tandem SH2 domain can bind a T cell antigen receptor zeta 3 TAM peptide in which both tyrosine residues are phosphorylated: Little or no binding is observed with peptides phosphorylated at only one tyrosine residue, or a nonphosphorylated peptide. Binding of the tandem SH2 domains to the other two TCR zeta TAM peptides and to a CD3 epsilon TAM peptide is also observed. All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70. The affinity of these peptides for the tandem SH2 construct demonstrates a hierarchy of TAM zeta 1, TAM zeta 2, TAM epsilon, TAM zeta 3 Homo sapiens ?
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Synonyms

Synonyms Comment Organism
tyrosine-protein kinase ZAP-70
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 Homo sapiens