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Literature summary for 2.7.10.2 extracted from

  • Chan, A.C.; Kadlecek, T.A.; Elder, M.E.; Filipovich, A.H.; Kuo, W.L.; Iwashima, M.; Parslow, T.G.; Weiss, A.
    ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency (1994), Science, 264, 1599-1601.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens autosomal recessive form of severe combined immunodeficiency disease in which ZAP-70 is absent as a result of mutations in the ZAP-70 gene. This absence is associated with defects in TCR signal transduction. Integral role in T cell activation and differentiation ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43403
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information autosomal recessive form of severe combined immunodeficiency disease in which ZAP-70 is absent as a result of mutations in the ZAP-70 gene. This absence is associated with defects in TCR signal transduction. Integral role in T cell activation and differentiation Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
tyrosine-protein kinase ZAP-70
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Homo sapiens