Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions. High-affinity SH3 ligands can compete for these interactions and specifically activate the Abl kinase | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure of the Abl-SH3 domain in complex with the high-affinity peptide ligand p41 at 1.6 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00519 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
Abl kinase | - |
Homo sapiens |
proto-oncogene tyrosine-protein kinase ABL1 | - |
Homo sapiens |