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Literature summary for 2.7.10.1 extracted from

  • Liu, Y.; Radhakrishnan, R.
    Computational delineation of tyrosyl-substrate recognition and catalytic landscapes by the epidermal growth factor receptor tyrosine kinase domain (2014), Mol. Biosyst., 10, 1890-1904.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00533
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?
ATP + NAEYLRV
-
Homo sapiens ADP + NAE-phospho-Y-LRV
-
?
ATP + VPEYINQ
-
Homo sapiens ADP + VPE-phosphoY-INQ
-
?
additional information protein tyrosine kinases select substrates with a glutamic acid at the P-1 position and a large hydrophobic amino acid at the P+1 position Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Egfr
-
Homo sapiens
epidermal growth factor receptor
-
Homo sapiens
RTK
-
Homo sapiens