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Literature summary for 2.7.10.1 extracted from
- Structural studies of GDNF family ligands with their receptors - Insights into ligand recognition and activation of receptor tyrosine kinase RET (2013), Biochim. Biophys. Acta, 1834, 2205-2212.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | requires a co-receptor, GFRalpha, for ligand recognition and activation | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuron | the enzyme is expressed primarily in peripheral enteric, sympathetic and sensory neurons, and in central motor, dopamine and noradrenaline neurons | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CLD1 | - |
Homo sapiens |
| CLD2 | - |
Homo sapiens |
| receptor tyrosine kinase | - |
Homo sapiens |
| RET | - |
Homo sapiens |
| RTK | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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