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Literature summary for 2.7.10.1 extracted from
- Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity (2010), J. Cell Sci., 123, 3857-3862.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEV | - |
Drosophila melanogaster |
| sevenless receptor tyrosine kinase | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Sevenless receptor tyrosine kinase binds directly to either the suppressor of cytokine signalling SOCS36E or the adaptor protein Drk, i.e. downstream of receptor kinase. In a mechanistic model, the competition between these two proteins for binding to the same docking site results in either attenuation of the Sevenless receptor tyrosine kinase transduction in cells that should not develop R7 photoreceptors or amplification of the Ras-MAPK signal only in the R7 precursor | Drosophila melanogaster |
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