Cloned (Comment) | Organism |
---|---|
expression in Sf9 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | identification of inhibitors by translation of structure-efficiency relationships of the substrates into structure-activity relationships of the inhibitors upon replacement of the phosphorylation warhead by an inactive mimetic | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0051 | - |
Ac-DYFE-6-chloro-W-NHMe | pH 7.4, 25°C | Homo sapiens | |
0.07 | - |
Ac-DYFGW-NHMe | pH 7.4, 25°C | Homo sapiens | |
0.232 | - |
YFEW | pH 7.4, 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08069 | IGF-1R | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Ac-DYFE-6-chloro-W-NHMe | substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner | Homo sapiens | ADP + Ac-DYpFE-6-chloro-W-NHMe | - |
? | |
ATP + Ac-DYFGW-NHMe | substrate identified by substrate-activity-screening methodology based on optimization of substrate YFEW in a modular manner | Homo sapiens | ADP + Ac-DYpFGW-NHMe | - |
? | |
ATP + YFEW | tetrapeptide identified by substrate profiling | Homo sapiens | ADP + YpFEW | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IGF-1R | - |
Homo sapiens |