Literature summary for 2.7.10.1 extracted from

Abou-Seri, S.M.
Synthesis and biological evaluation of novel 2,4-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors (2010), Eur. J. Med. Chem., 45, 4113-4121.

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitor N-ethyl-5-[2-[4-(5-(ethylamino)-1,3,4-thiadiazol-2-yl)phenylamino]-phenyl]-1,3,4-thiadiazol-2-amine. The 4-(5-ethylamino-1,3,4-thiadiazol-2-yl)phenyl moiety binds the adenine binding pocket. The thiadiazole ring nitrogen N4 interacts with the backbone NH of residue Met793 via hydrogen bond and the 5-ethylamino NH is engaged in a second hydrogen bond with the side-chain OH of Thr 790. The ethyl group is projecting in this narrow pocket near to the Thr790 side-chain	Homo sapiens

Crystallization (Comment)

Organism

molecular docking of inhibitor N-ethyl-5-[2-[4-(5-(ethylamino)-1,3,4-thiadiazol-2-yl)phenylamino]-phenyl]-1,3,4-thiadiazol-2-amine. The 4-(5-ethylamino-1,3,4-thiadiazol-2-yl)phenyl moiety binds the adenine binding pocket. The thiadiazole ring nitrogen N4 interacts with the backbone NH of residue Met793 via hydrogen bond and the 5-ethylamino NH is engaged in a second hydrogen bond with the side-chain OH of Thr 790. The ethyl group is projecting in this narrow pocket near to the Thr790 side-chain

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
2-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]-N-[4-[5-(benzylthio)-1,3,4-oxadiazol-2-yl]phenyl]aniline	49% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00073 mM	Homo sapiens
4-ethyl-3-[2-[4-(4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenylamino]phenyl]-1H-1,2,4-triazole-5(4H)-thione	52% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00238 mM	Homo sapiens
N-ethyl-5-[2-[4-(5-(ethylamino)-1,3,4-thiadiazol-2-yl)phenylamino]-phenyl]-1,3,4-thiadiazol-2-amine	97.7% inhibition at 0.01 mM, antiproliferative activity on human breast cancer cell line MCF-7, IC50 value 0.00094 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00533	epidermal growth factor receptor tyrosine kinase	-

Synonyms

Synonyms	Comment	Organism
epidermal growth factor receptor tyrosine kinase	-	Homo sapiens