Application | Comment | Organism |
---|---|---|
medicine | aldehyde dehydrogenase ALDH1A1-positive lung cancer cells display resistance to gefitinib, compared to ALDH1A1-negative lung cancer cells. Lung cancer cells with resistance to EGFR tyyrosine kinase inhibitors and chemotherapy drugs contain significantly increased proportions of ALDH1A1-positive cells. ALDH1A1 positivity in cancer stem cells may confer resistance to EGFR tyrosine kinase inhibitors in lung cancer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-9 cell | gefitinib-sensitive cells with EGFR mutation, and derivative PC9/gef, i.e. gefitinib-resistant cells | Homo sapiens | - |