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Literature summary for 2.7.10.1 extracted from

  • Huang, C.; Tsai, M.; Chang, T.; Tang, W.; Chen, S.; Lai, H.; Lin, T.; Yang, J.; Yang, P.; Shih, J.; Lin, S.
    ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors (2013), Cancer Lett., 328, 144-151.
    View publication on PubMed

Application

Application Comment Organism
medicine aldehyde dehydrogenase ALDH1A1-positive lung cancer cells display resistance to gefitinib, compared to ALDH1A1-negative lung cancer cells. Lung cancer cells with resistance to EGFR tyyrosine kinase inhibitors and chemotherapy drugs contain significantly increased proportions of ALDH1A1-positive cells. ALDH1A1 positivity in cancer stem cells may confer resistance to EGFR tyrosine kinase inhibitors in lung cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
PC-9 cell gefitinib-sensitive cells with EGFR mutation, and derivative PC9/gef, i.e. gefitinib-resistant cells Homo sapiens
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