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Literature summary for 2.7.10.1 extracted from

  • Ischenko, I.; Camaj, P.; Seeliger, H.; Kleespies, A.; Guba, M.; De Toni, E.N.; Schwarz, B.; Graeb, C.; Eichhorn, M.E.; Jauch, K.W.; Bruns, C.J.
    Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling (2008), Oncogene, 27, 7212-722.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
5-fluorouracil
-
 Homo sapiens

Application

Application Comment Organism
medicine a potential mechanism of action of Src kinase inhibitors on 5-fluorouracil chemosensitivity may be linked to the inhibition of 5-fluorouracil-induced EGFR-AKT activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine PP2, combination of 5-fluorouracil-PP2 decreases the 5-fluorouracil-induced activation of EGFR-AKT pathway Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell
-
 Homo sapiens
-
L3.6pl cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Egfr
-
 Homo sapiens
epidermal growth factor receptor
-
 Homo sapiens