Activating Compound | Comment | Organism | Structure |
---|---|---|---|
capsaicin | c-kit receptor expression is significantly up-regulated in medium-sized dorsal root ganglia neurons after neonatal capsaicin treatment | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | c-kit receptor is mainly expressed in peptidergic small-sized dorsal root ganglia neurons and may be involved in pain regulation both peripherally and centrally | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | selective elimination of unmyelinated C-fibers by neonatal capsaicin treatment results in marked reduction of the c-kit receptor and calcitonin gene-related peptide expression in the superficial layer of the spinal cord. C-kit receptor expression is significantly down-regulated in medium-sized dorsal root ganglia neurons after nerve injury | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male ddY mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | expressed in small- and medium sized dorsal root ganglia neurons, c-kit receptor is co-expressed in 58.4% of calcitonin gene-related peptide-positive, but only 5.1% of isolectin B4-positive, dorsal root ganglia neurons | Mus musculus | - |
spinal cord | in the superficial layer of the dorsal horn and co-localized with calcitonin gene-related peptide in central terminals of peptidergic small-sized dorsal root ganglia neurons | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
c-kit receptor | - |
Mus musculus |
c-Kit receptor tyrosine kinase | - |
Mus musculus |