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Literature summary for 2.7.10.1 extracted from

  • Milner, C.S.; Hansen, T.M.; Singh, H.; Brindle, N.P.
    Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis (2009), Microvasc. Res., 77, 187-191.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
angiopoietin-1 activates Homo sapiens

Application

Application Comment Organism
additional information Tie1 does not transduce anti-apoptotic or anti-permeability effects of Ang1 in endothelial cells Homo sapiens
additional information Tie2 mediates the inhibitory effects of Ang1 on endothelial permeability and apoptosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA siRNA directed against Tie1 suppresses expression of the receptor by more than 90%. Ang1 inhibition of permeability is not affected by suppression of Tie1 expression. Ability of Ang1 to inhibit induction of apoptosis in response to serum deprivation is not diminished by suppression of Tie1 expression; siRNA directed against Tie2 suppresses expression of the receptor by more than 90%. Ang1 inhibits endothelial monolayer permeability, which is prevented by suppression of Tie2 expression. Ability of Ang1 to inhibit induction of apoptosis in response to serum deprivation is completely blocked by suppression of Tie2 expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P35590
-
-
Homo sapiens Q02763
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
 Homo sapiens
-
HUVEC cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
receptor tyrosine kinase
-
 Homo sapiens
Tie1
-
 Homo sapiens
Tie2
-
 Homo sapiens