Activating Compound | Comment | Organism | Structure |
---|---|---|---|
agrin | MuSK becomes rapidly internalized in response to agrin, which appears to be required for induced acetylcholine receptor clustering | Mus musculus | |
N-ethylmaleimide sensitive factor | an appropriate level of N-ethylmaleimide sensitive factor and its ATPase activity may be required for MuSK endocytosis and subsequent activation | Mus musculus |
Application | Comment | Organism |
---|---|---|
additional information | role of N-ethylmaleimide sensitive factor in regulating MuSK endocytosis and subsequent signaling in response to agrin stimulation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
coexpression of HA-tagged MuSK with Myc-tagged N-ethylmaleimide sensitive factor wild-type or mutant constructs in HEK-293 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | only MuSK deletion mutants containing the intact kinase domain can bind to N-ethylmaleimide sensitive factor. Deletion of the C terminus (13 amino acids) has no effect on MuSK binding to N-ethylmaleimide sensitive factor. Deletion of the middle 30 amino acids in the juxtamembrane, including Y556, a tyrosine implicated in agrin signaling, has no apparent effect on binding to N-ethylmaleimide sensitive factor. Deletion of any 30 amino acids in the kinase domain or in the region linking the juxtamembrane and kinase domains abolishes the binding activity, with the exception of one deletion mutant, DELTA739-768 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dynamin K44A | inhibits agrin-induced MuSK endocytosis | Mus musculus | |
additional information | suppression of N-ethylmaleimide sensitive factor expression or N-ethylmaleimide sensitive factor mutation attenuate MuSK downstream signaling | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Mus musculus | 9986 | - |
cytoplasm | cytoplasmic domain | Mus musculus | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61006 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
muscle-specific receptor tyrosine kinase | - |
Mus musculus |
MuSK | - |
Mus musculus |