Literature summary for 2.7.10.1 extracted from

Ueno, Y.; Sakurai, H.; Tsunoda, S.; Choo, M.K.; Matsuo, M.; Koizumi, K.; Saiki, I.
Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells (2008), Int. J. Cancer, 123, 340-347.

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Activating Compound

Activating Compound	Comment	Organism	Structure
heregulin	induces phosphorylation of ErbB3 and metastatic properties including MMP-9 expression, invasion, adhesion and experimental lung metastasis in vivo	Mus musculus
heregulin	rapidly induces phosphorylation of EGFR	Mus musculus

Application

Application	Comment	Organism
medicine	heregulin-induced activation of ErbB3 via EGFR (EGFR is a possible heterodimeric counterpart of ErbB3) promotes tumor growth and metastasis of melanoma cells	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
PD153035	inhibits tyrosine kinase activity of EGFR and whereby blocks cellular responses of activated ErbB3. It inhibits heregulin-induced VEGFA expression; inhibits tyrosine kinase activity of EGFR and whereby blocks cellular responses of activated ErbB3. It inhibits heregulin-induced VEGFA expression	Mus musculus
shRNA	sh-ErbB3 cells normally metastasize to the lung, but the heregulin-induced increase in metastasis is completely abrogated. Inactivation of ErbB3 by shRNA does not directly influence the formation of metastatic colonies in the experimental metastasis model, although heregulin-induced enhancement is completely dependent on ErbB3. However, spontaneous metastasis by inoculating the cells without heregulin stimulation into the foot pad is significantly decreased	Mus musculus
siRNA	local injection of siRNA against ErbB3 with the atolocollagen results in a decrease in the tumor growth of parent B16-BL6 cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q01279	-	-
Mus musculus	Q61526	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B16-BL6 cell	overexpression of functional ErbB3	Mus musculus	-
additional information	overexpression of EGFR in CBO140C12 cells	Mus musculus	-
additional information	overexpression of ErbB2, but not ErbB3 in CBO140C12 cells	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
Egfr	-	Mus musculus
ErbB2	-	Mus musculus
ErbB3	-	Mus musculus
ErbB3 receptor tyrosine kinase	-	Mus musculus

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Release 2023.1 (January 2023)