Activating Compound | Comment | Organism | Structure |
---|---|---|---|
hepatocyte growth factor | activation of c-MET occurs in response to binding the physiological ligand hepatocyte growth factor | Chlorocebus aethiops | |
internalin B | activation of c-MET occurs in response to binding the internalin B protein of Listeria monocytogenes | Chlorocebus aethiops | |
additional information | ligand-dependent nonlinear increase in the level of c-MET phosphorylation in serum-starved Vero cells. c-MET activation response is sensitive to the dimer autophosphorylation rate. Stimulated monomeric c-MET, although clearly an active kinase molecule, is incapable of existing in an activated (i.e., phosphorylated, signaling competent) state due to synergistic effects of the biochemical properties associated with the c-MET monomeric state | Chlorocebus aethiops |
Application | Comment | Organism |
---|---|---|
additional information | model of c-MET activation. Relative importance of the main regulatory processes that work in concert to sharply switch between an inactive and active c-MET state. Importance of dimerization mediated changes in c-MET kinetic, biochemical, and dephosphorylation properties for enabling activation specificity. Ligand-stimulated c-MET is a highly competent signaling species and its activation is sensitive to changes in its biochemical parameters | Chlorocebus aethiops |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlorocebus aethiops | Q2IBA6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Vero cell | - |
Chlorocebus aethiops | - |
Synonyms | Comment | Organism |
---|---|---|
c-met | - |
Chlorocebus aethiops |
hepatocyte growth factor receptor | - |
Chlorocebus aethiops |