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Literature summary for 2.7.10.1 extracted from

  • Corbacioglu, S.; Kilic, M.; Westhoff, M.A.; Reinhardt, D.; Fulda, S.; Debatin, K.M.
    Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin (2006), Blood, 108, 3504-3513.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Ba/F3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
imatinib IC50: 30 nM Homo sapiens
Rapamycin IC50: 3 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myeloblast
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
KIT
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
IC50: 3 nM Homo sapiens Rapamycin
0.00003
-
IC50: 30 nM Homo sapiens imatinib